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For information about clinical trials sponsored by private sources, contact: In some cases, Noonan syndrome may be suspected before birth prenatally based upon results of fetal ultrasonography, a specializing imaging technique in which sound waves are used to create an image of the developing fetus. In the normal heart, a small opening is present between the two atria foramen ovale at birth.

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Long-term GH treatment improves adult height in children with Noonan syndrome with and without mutations in protein tyrosine kinase phosphatase, non-receptor-type Associated symptoms and findings may include fatigue, brief fainting episodes syncope during exertion or exercise, and heart failure. In addition, some affected infants may have malformations of certain lymph vessels congenital lymphatic dysplasia.

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Approximately two thirds of infants with Noonan syndrome also have heart cardiac abnormalities at birth congenital heart defects. In addition, most individuals with the disorder experience growth delays, moderate to severe intellectual disability, and abnormal delays in the acquisition of skills requiring the coordination of mental and muscular activity psychomotor retardation. Noonan syndrome is a genetic disorder that is typically evident at birth congenital.